For a standalone page or one that you embed as an iframe into your own website, most definitely. (See here why sending a video in an email won't work).
Using the Premium editor:
After downloading the template into SelectReads, you can edit the html right in there and throw in a youtube animation:
http://screencast.com/t/SmImhI9fr
Here is an example of such a static page:
http://bookdb.nextgoodbook.com/newsletter/e/677e85ca26761d92426c4e68ae5e4f7f/16655